Steroid induced muscle wasting

A very typical case of severe cholestasis due to anabolic steroid use.  Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid.  The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss.  The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy.  The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed.  Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis.  Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.

Sacks et al. (2005) reported the case of a 72-year-old man, described as professionally successful, intelligent, and cultivated, with polymyalgia rheumatica, who after being treated with prednisone developed a psychosis and dementia , which several behavioral neurology and neuropsychiatry consultants initially diagnosed as early dementia or Alzheimer's disease . [12] Large dosage variations in the patient's medication (including a self-increased dosage from 10 mg/day to as much as 100 mg/day for at least 3 months) produced extreme behavioral changes, from missed appointments to physical altercations, and eventually admission to a psychiatric ward and later to a locked Alzheimer facility. During this time, neuropsychological testing showed a decline in the patient's previously superior IQ as well as deficits in memory, language, fluency, and visuospatial function, which given the patient's age was considered to be compatible with early dementia. When the steroid treatment ended after a year, the patent's confusion and disorganized appearance stopped immediately. Within several weeks, testing showed strong improvement in almost all cognitive functions. His doctors were surprised at the improvement, since the results were inconsistent with a diagnosis of dementia or Alzheimer's. Testing after 14 months showed a large jump in Full Scale IQ from 87 to 124, but mild dysfunction in executive function, memory, attentional control, and verbal/nonverbal memory remained. [12]

During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.

I have somewhat extensively studied DNP prior to, during and after my own experiments with this incredibly enticing poison.  Surely you didn’t think I was writing all this based on sheer conjecture, hypothesis, and study?  There is also some great DNP dialoguing within my Steroid .com signature. 

No matter how safe you hear a given herb, chemical, or drug (regardless of dosage) is there is always the possibility of individual sensitivities.  This issue becomes greatly magnified with regard to poisons because of the potential for serious injury and fatality.  Even the name Di-NITRO-phenol is remarkably engaging to a gear user and “no” proper administration without pre-existing hypersensitivities won’t kill you, but it does all come down to a single truth.  A truth you may have arrived at prior to the halfway mark in this piece, the same truth that the author of a great documented journey through the DNP experience, ‘The Inferno: My Week on DNP’ (http://-/portal_includes/articles/2006/06-068-), Vets and Hall-of-Famers like Marcus, Nark, Giant, Booz - just ask them, myself (magic32) and numerous others have come to realize…

Laws and Penalties:  Concerns over growing illegal AAS abuse by teenagers, and many of the just discussed long-term effects, led Congress in 1991 to place the whole AAS class of drugs into Schedule III of the Controlled Substances Act (CSA).  Under this legislation, AAS are defined as any drug or hormonal substance, chemically and pharmacologically related to T (other than estrogens, progestins, and corticosteroids) that promotes muscle growth.  The possession or sale of AAS without a valid prescription is illegal.  Since 1991, simple possession of illegally obtained AAS carry a maximum penalty of one year in prison and a minimum $1,000 fine if this is an individual’s first drug offense.  The maximum penalty for trafficking (selling or possessing enough to be suspected of selling) is five years in prison and a fine of $250,000 if this is the individual’s first felony drug offense.  If this is the second felony drug offense, the maximum period of imprisonment and the maximum fine both double.  While the above listed penalties are for federal offenses, individual states have also implemented fines and penalties for illegal use of AAS.  State executive offices have also recognized the seriousness of AAS abuse and other drugs of abuse in schools. For example, the State of Virginia enacted a law that will allow student drug testing as a legitimate school drug prevention program (48, 49).

Steroid induced muscle wasting

steroid induced muscle wasting

I have somewhat extensively studied DNP prior to, during and after my own experiments with this incredibly enticing poison.  Surely you didn’t think I was writing all this based on sheer conjecture, hypothesis, and study?  There is also some great DNP dialoguing within my Steroid .com signature. 

No matter how safe you hear a given herb, chemical, or drug (regardless of dosage) is there is always the possibility of individual sensitivities.  This issue becomes greatly magnified with regard to poisons because of the potential for serious injury and fatality.  Even the name Di-NITRO-phenol is remarkably engaging to a gear user and “no” proper administration without pre-existing hypersensitivities won’t kill you, but it does all come down to a single truth.  A truth you may have arrived at prior to the halfway mark in this piece, the same truth that the author of a great documented journey through the DNP experience, ‘The Inferno: My Week on DNP’ (http://-/portal_includes/articles/2006/06-068-), Vets and Hall-of-Famers like Marcus, Nark, Giant, Booz - just ask them, myself (magic32) and numerous others have come to realize…

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