Years ago I was taking Enbrel for RA primarily in my hands and it was working. Then I developed Afib and congestive heart failure. I had to have heart ablation and they wouldn’t put me back on Enbrel suspecting it was a causative factor in my heart problems. I am a health nut and have taken the best of antiinflamatory supplements but only prednisone 5mg twice daily works. If I don’t take it regularly I get a bad attack (terrible shakes, chills, severe pain in hands, neck, upper arm – I can’t function. I have followed your blogs for some time and would like to get some treatment and eventually get off prednisone. Isn’t there anything you can do to help me? Eileen Miller healthsense-gnld@
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]