WARNING: This medicine can have very serious side effects and has been misused and abused. Do not use with other medicines that slow your breathing or mental activity, or cause sleepiness. XYREM has caused changes in alertness (or consciousness) and trouble breathing (respiratory depression). Call your doctor right away if you have any of these serious side effects. These effects happened even when XYREM was given in recommended doses. In studies, almost all of the patients with narcolepsy who were given XYREM were also taking medicines to help them stay awake during the day. XYREM is a form of gamma hydroxybutyrate (GHB). Abuse of GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), very low levels of alertness (or consciousness), coma, and death.
Since its approval, metformin has become the most commonly recommended blood glucose-lowering medication to treat type 2 diabetes. In recent years it has significantly replaced sulfonylureas, such as glipizide and glyburide. Today both the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), and the American Association of Clinical Endocrinologists (AACE) generally recommend that people with type 2 diabetes start taking metformin when they are diagnosed to help treat insulin resistance and maximize insulin sensitivity
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