Aldosterone and cortisol (a glucosteroid ) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids circulate at roughly 100 times the level of mineralocorticoids. An enzyme exists in mineralocorticoid target tissues to prevent overstimulation by glucocorticoids. This enzyme, 11-beta hydroxysteroid dehydrogenase type II ( Protein:HSD11B2 ), catalyzes the deactivation of glucocorticoids to 11-dehydro metabolites. Licorice is known to be an inhibitor of this enzyme and chronic consumption can result in a condition known as pseudohyperaldosteronism . 
Diseases of the endocrine system are common, including conditions such as diabetes mellitus , thyroid disease, and obesity . Endocrine disease is characterized by irregulated hormone release (a productive pituitary adenoma ), inappropriate response to signaling ( hypothyroidism ), lack of a gland ( diabetes mellitus type 1 , diminished erythropoiesis in chronic renal failure ), or structural enlargement in a critical site such as the thyroid ( toxic multinodular goitre ). Hypofunction of endocrine glands can occur as a result of loss of reserve, hyposecretion, agenesis , atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or hyperstimulation.