NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
A blood loss of 80 cc (5 tablespoons) or more is an abnormally heavy flow. Signs that your flow may be abnormally heavy include soaking through more than one tampon or sanitary pad in an hour, for several hours at a time. You may need to double up on sanitary pads, or use both a tampon and a pad. An abnormally heavy flow may cause you to wake up during the night because you need to change protection. You may not be able or willing to participate in your normal activities because your flow is too heavy. Sometimes, an abnormally heavy flow will contain large blood clots, or last more than a week. Also, an abnormally heavy flow can cause you to experience the following symptoms, which may be an indication of anemia: