Tamoxifen is one of three drugs in an anti-angiogenetic protocol developed by Dr. Judah Folkman , a researcher at Children's Hospital at Harvard Medical School in Boston. Folkman discovered in the 1970s that angiogenesis – the growth of new blood vessels – plays a significant role in the development of cancer. Since his discovery, an entirely new field of cancer research has developed. Clinical trials on angiogenesis inhibitors have been underway since 1992 using myriad different drugs. The Harvard researchers developed a specific protocol for a golden retriever named Navy who was cancer-free after receiving the prescribed cocktail of celecoxib , doxycycline , and tamoxifen – the treatment subsequently became known as the Navy Protocol.  Furthermore, tamoxifen treatment alone has been shown to have anti-angiogenetic effects in animal models of cancer which appear to be, at least in part, independent of tamoxifen's ER antagonist properties. 
About the National Institute on Drug Abuse (NIDA): The National Institute on Drug Abuse (NIDA) is a component of the National Institutes of Health, . Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. Fact sheets on the health effects of drugs and information on NIDA research and other activities can be found at , which is now compatible with your smartphone, iPad or tablet. To order publications in English or Spanish, call NIDA’s DrugPubs research dissemination center at 1-877-NIDA-NIH or 240-645-0228 (TDD) or email requests to drugpubs@ . Online ordering is available at . NIDA’s media guide can be found at /publications/media-guide/dear-journalist , and its easy-to-read website can be found at . You can follow NIDA on Twitter and Facebook .
After the ripping stage has passed, it is likely that diet will change back to the same as before, and the old training routine may return also. Less cardiovascular exercise may be used and a change in supplements might take place. Some body builders lose around a 20 or more pounds at the peak of the ripping period, and they would then gain it all back again, sometimes with the desire to put on extra weight. If they wish to put on weight then it is usually muscle. It might be a goal for them to lose 20 pounds of fat next year but be a few pounds heavier than they were before, indicating an increase in muscle growth .