Actin ring is one of cell adhesion structures, which plays an essential role in osteoclast function ( 18 ). We found that the TRAP-positive MNCs formed actin rings in the RANKL group and LMHFV group. The number of the actin rings was decreased in the LMHFV group compared to that in the RANKL group. Moreover, the distance between the basolateral membrane facing the marrow space and the ruffled border (osteoclast height), an index of osteoclast polarization, was reduced in the LMHFV group (Figure 3 ). These results suggest that LMHFV disrupts actin cytoskeletal organization.
Think you can handle the nuclear intensity of SUPERNOVA? Working within minutes, each scoop of this hard-hitting pre-workout will smash your body and blow your mind with devastating energy, explosive power and skin-splitting pumps for the most insane workouts of your life! With it’s 9 clinically-proven ingredient dosages fully exposed it's obvious to see that SUPERNOVA is a force unlike anything you have ever experienced. Every rep fills your veins with a massive 6000mg of citrulline malate, 1600mg of CarnoSyn® Beta Alanine, 1500mg of betaine anhydrous to shock your muscles into rapid growth. Supernova’s exclusive 4X Energy Core Technology and psychoactive nootropics work simultaneously to ignite your nervous system and overload your focus and endurance, leaving the competition lightyears behind. Are you strong enough to go Supernova?